Features available in the E60 initially included iDrive (first introduced in the E65 7 Series), active cruise control, voice control,^[6] Bi-Xenon headlights, run-flat tyres, active width adjustment seats,^[5] active anti-roll bars^[15] and active steering.^[9] Safety-related items include Dynamic Stability Control (DSC), head-up display,^[16] adaptive headlights, night vision and active headrests.

Over the E60's lifespan, the following features were added: a simplified iDriveinterface,^[17] Active Cruise Control with Stop & Go,^[18] LED rear lights,^[19] Lane Departure Warning^[6] and Brake Force Display.

The E60 had many entertainment features for its time, such as an optional Harman Kardon Logic 7 premium amplified Surround Sound audio system with multi-band graphical equalizer, optional HD Radio, optional Satellite Radio, an optional auxiliary audio input jack (standard starting with the 2008 model year, optional USB integration for mobile devices, an optional glove compartment-mounted multi-disc CD changer unit, standard MP3 reading capabilities for the CD player, standard voice control, standard Bluetooth hands-free wireless telephone integration, and an A/M-F/M with standard Weather Radio (Weather Band) tuner.

Every E60 featured BMW Assist with an SOS button located in the overhead control panel. However, older E60 vehicles equipped with AMPS cellular technology (or older GSM digital cellular technology) ceased to function after 2016. E60 owners with affected vehicles could have the system upgraded with modernized equipment, or receive a credit for their currently active BMW Assist services.

Finally, in 2005, the E60 introduced BMW's Comfort Access keyless entry system. The Comfort Access system became standard equipment on all E60's beginning in mid-2006, though a traditional key fob with integrated key and traditional ignition system was available as well in early E60 models.